1-[2-(4-Nitrophenyl)ethyl]piperidine → 4-(2-(Piperidin-1-yl)ethyl)aniline

HRID 1277024

반응식

HRID 1277024 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1

참가 물질

3

반응물 1

HCID 2205731-[2-(4-Nitrophenyl)ethyl]piperidine

생성물 1

HCID 107034004-(2-(Piperidin-1-yl)ethyl)aniline수율 100.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In ethanol (100 ml) was dissolved 1-[2-(4-nitrophenyl)ethyl]piperidine (24.8 g), and to the mixture was added dried 10% palladium on carbon(1.24 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 86 hours. The palladium was filtered off, and the filtrate was concentrated to give 1-[2-(4-aminophenyl)ethyl]-piperidine (21.7 g) as pale brown oil.

후처리

  1. additionto the mixture was added
  2. dry with materialdried 10% palladium on carbon(1.24 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-283da6d0723b47458453671459b96a32
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06166006

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