Potassium Hydroxide → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-
반응식
[C:1]([CH2:7][C:8]#[N:9])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[OH-].[K+].S(O)(O)(=O)=O.[NH2:17]O>O>[NH2:9][C:8]1[CH:7]=[C:1]([C:2]([CH3:5])([CH3:4])[CH3:3])[O:6][N:17]=1참가 물질
5
실험 절차
To a suspension of pivaloylacetonitrile (1.252 g) and 86% potassium hydroxide (0.717 g) in water (20 ml) is added hydroxylamine sulfate (0.903 g) at 25° C. and the mixture is stirred for 3 minutes. pH 8.30. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (1.204 g). Yield, 85.9%. Purity, 95.8%.
후처리
- additionThe reaction mixture is treated as in Example 2
출처 및 근거
- ORD 기록
- ord-26f5c1e9929c44e3ac1479cd52b74e18
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04256899
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