Methyl 2-(methyl(4-nitrobenzyl)amino)acetate → HCID 18472314, 화합물

HRID 1277237노트

반응식

HRID 1277237 반응식
[CH3:1][O:2][C:3](=[O:17])[CH2:4][N:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=1)[CH3:6]>C(O)(=O)C>[CH3:1][O:2][C:3](=[O:17])[CH2:4][N:5]([CH2:7][C:8]1[CH:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=1)[CH3:6]

참가 물질

3

반응물 1

HCID 18472662Methyl 2-(methyl(4-nitrobenzyl)amino)acetate

생성물 1

HCID 18472314HCID 18472314, 화합물수율 57.6%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

In acetic acid (100 ml) was dissolved N-(4-nitrobenzyl)sarcosine methyl ester (5.96 g), and to the mixture was added little by little reduced iron (7 g). The mixture was stirred at room temperature overnight. The solvent was evaporated, and to the residue was added ethyl acetate. The precipitates were filtered off, and the filtrate was washed with sodium hydroxide solution, water and saturated brine, and dried with anhydrous magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the resulting residue was purified with silica gel column chromatography (ethyl acetate/hexane) to give N-(4-aminobenzyl)sarcosine methyl ester (3.0 g) as red oil.

후처리

  1. customThe solvent was evaporated
  2. additionto the residue was added ethyl acetate
  3. filtrationThe precipitates were filtered off
  4. washthe filtrate was washed with sodium hydroxide solution, water and saturated brine
  5. dry with materialdried with anhydrous magnesium sulfate
  6. customUnder reduced pressure, the solvent was evaporated
  7. customthe resulting residue was purified with silica gel column chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-e018448e98c845009b33a4748ef175af
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06166006

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