Ethanolamine → [2-(2-Hydroxyethylamino)-2-oxoethoxy]acetic acid

반응식

CS([O-])(=O)=O.[C:6]1(=[O:13])[O:12][C:10](=[O:11])[CH2:9][O:8][CH2:7]1.[NH2:14][CH2:15][CH2:16][OH:17]>>[OH:17][CH2:16][CH2:15][NH:14][C:10](=[O:11])[CH2:9][O:8][CH2:7][C:6]([OH:12])=[O:13]

참가 물질

반응물 3

HCID 700Ethanolamine

HCID 782321,4-Dioxane-2,6-dione

HCID 85257Methanesulfonate

생성물 1

HCID 20558836[2-(2-Hydroxyethylamino)-2-oxoethoxy]acetic acid

실험 절차

methanesulfonate by (a) reacting diglycolic anhydride and 2-aminoethanol to produce [2-(2-hydroxyethylamino)-2-oxoethoxy]acetic acid, (b) heating to cyclixe the latter to obtain 4-(2-hydroxyethyl)-3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 2-(3,5-dioxomorpholino)ethyl methanesulfonate and (d) reacting the mesylate with piperidine.

출처 및 근거

ORD 기록: ord-69a71491bb6d4704857d6737cffbdffb
출처 데이터셋: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04256891

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