Sulfuric Acid → HCID 23454145, 화합물

HRID 1277480노트

반응식

HRID 1277480 반응식
[C:1]1(=[O:14])[N:5]([CH2:6][C:7]#[N:8])[C:4](=[O:9])[C:3]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:2]12.[CH3:15][C:16](O)([CH2:18][CH:19]([CH3:23])[CH2:20][CH2:21][CH3:22])[CH3:17].S(=O)(=O)(O)[OH:26]>C(O)(=O)C>[C:4]1(=[O:9])[N:5]([CH2:6][C:7]([NH:8][C:16]([CH3:17])([CH3:15])[CH2:18][CH:19]([CH3:23])[CH2:20][CH2:21][CH3:22])=[O:26])[C:1](=[O:14])[C:2]2=[CH:13][CH:12]=[CH:11][CH:10]=[C:3]12

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 345881N-(Cyanomethyl)-phthalimideHCID 5221872,4-Dimethylheptan-2-ol

생성물 1

HCID 23454145HCID 23454145, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2-Phthalimidoacetonitrile (3.85 g) was dissolved in glacial acetic acid at 70° and 2,4-dimethylheptan-2-ol (3 g) was added; followed dropwise by conc. sulphuric acid (2.8 ml) the temperature being maintained between 65° and 70°. The final mixture was stirred for 15 minutes and then added slowly to ice cold water (150 ml). The resulting solid was collected, washed with water and dried in vacuo. It was dissolved in hot benzene, a little insoluble material filtered off and light petroleum (b.p. 40°-60° ) added to give 2-phthalimido-N-(1,1,3-trimethylhexyl)acetamide as a colourless solid, m.p. 131.6°.

후처리

  1. temperaturebeing maintained between 65° and 70°
  2. customThe resulting solid was collected
  3. washwashed with water
  4. customdried in vacuo
  5. dissolutionIt was dissolved in hot benzene
  6. filtrationa little insoluble material filtered off
  7. additionlight petroleum (b.p. 40°-60° ) added

출처 및 근거

ORD 기록
ord-336a86f956ff426da5e66c4eb9c0ba39
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04277498

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