Acetonitrile → HCID 53971717, 화합물

HRID 1277576노트

반응식

[CH3:1][C:2]([OH:10])([CH2:4][CH2:5][CH2:6][C:7](=O)[CH3:8])[CH3:3].[OH-].[K+].[C:13](#[N:15])[CH3:14]>>[CH3:8][C:7]1([CH2:14][C:13]#[N:15])[CH2:6][CH2:5][CH2:4][C:2]([CH3:1])([CH3:3])[O:10]1

참가 물질

반응물 3

HCID 6342Acetonitrile

HCID 14797Potassium Hydroxide

HCID 787626-Hydroxy-6-methyl-2-heptanone

생성물 1

HCID 53971717HCID 53971717, 화합물

실험 절차

The distillation residue of the second reaction is again recycled for a third synthesis after adding a further 122.7 g of 94.5% 2-methyl-heptan-2-ol-6-one (0.80525 moles), 5.2853 g of 86% KOH and acetonitrile in the usual ratio. After the reaction, distillation gives 82.0 g of 2,6,6-trimethyl-2-cyanomethyltetrahydropyran (0.49099 moles) in the distillate, together with the unconverted hydroxyketone.

후처리

customThe distillation residue of the second reaction
customis again recycled for a third synthesis
customAfter the reaction, distillation

출처 및 근거

ORD 기록: ord-268c091508c74b48a1ba7e4d406dab9c
출처 데이터셋: uspto-grants-1981_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04278602

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