Iodine → 2-Hydroxymethyl-3-methyl-5-iodothiophene

HRID 127763

반응식

HRID 127763 반응식
[I:1]I.[OH:3][CH2:4][C:5]1[S:6][CH:7]=[CH:8][C:9]=1[CH3:10]>C1C=CC=CC=1>[OH:3][CH2:4][C:5]1[S:6][C:7]([I:1])=[CH:8][C:9]=1[CH3:10]

참가 물질

4

반응물 2

HCID 807IodineHCID 12875263(3-Methylthiophen-2-yl)methanol

생성물 1

HCID 191047842-Hydroxymethyl-3-methyl-5-iodothiophene

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

6.58 G. (33 mmol) of mercuric oxide and 7.62 g. (30 mmol) of iodine were added alternately in small amounts to a vigorously stirred solution of 3.84 g. (30 mmol) of 2-hydroxymethyl-3-methylthiophene in 30 ml. of benzene. The reaction was kept at room temperature by cooling with an ice bath. The orange mercuric iodide which precipitated was filtered and washed well with benzene. The combined organic solutions were washed with sodium thiosulfate and saturated sodium chloride solution, dried and evaporated to yield crude 2-hydroxymethyl-3-methyl-5-iodothiophene as a colorless oil.

후처리

  1. customwas kept at room temperature
  2. temperatureby cooling with an ice bath
  3. customThe orange mercuric iodide which precipitated
  4. filtrationwas filtered
  5. washwashed well with benzene
  6. washThe combined organic solutions were washed with sodium thiosulfate and saturated sodium chloride solution
  7. customdried
  8. customevaporated

출처 및 근거

ORD 기록
ord-8f91c11da0aa4924b866efa4a5fe7acc
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04256878

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