Formic Acid → N-(3-chloro-4-fluorophenyl)formamide

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[CH:10](O)=[O:11]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][CH:10]=[O:11])[CH:6]=[CH:7][C:8]=1[F:9]

참가 물질

반응물 2

HCID 284Formic Acid

HCID 97083-Chloro-4-fluoroaniline

생성물 1

HCID 237238N-(3-chloro-4-fluorophenyl)formamide

반응 조건

온도: 106 °C

실험 절차

A mixture of 100 g of 3-chloro-4-fluoroaniline and 400 ml of 97% formic acid was refluxed (106° C.) for three hours. The mixture then was poured into ice water and the resulting mixture was filtered. The solid was washed with water and dried to give N-(3-chloro-4-fluorophenyl)formamide (J. Org. Chem., 26, 2563 (1961)) (1A), as a colorless crystalline solid, mp: 94°-97° C.

후처리

filtrationthe resulting mixture was filtered
washThe solid was washed with water
customdried

출처 및 근거

ORD 기록: ord-ee6c4f4eaa2d42d0bde85d3dcfc65e8a
출처 데이터셋: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04257805

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