Phosgene → 4-(2-Naphthyloxy)phenyl isocyanate

HRID 1278169노트

반응식

HRID 1278169 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1.[C:19](Cl)(Cl)=[O:20]>C1(C)C=CC=CC=1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:18]=[CH:17][C:15]([N:16]=[C:19]=[O:20])=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 6371PhosgeneHCID 35808292-(4-Aminophenoxy)naphthalene

생성물 1

HCID 127740664-(2-Naphthyloxy)phenyl isocyanate수율 92.3%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

A solution of 4-(2-naphthyloxy)aniline (4 g) in toluene (100 ml) was dropwise added to a solution of phosgene (3.5 g) in toluene (50 ml), and the resulting mixture was refluxed for 1 hour. After removal of the solvent from the reaction mixture by distillation under reduced pressure, the residue was distilled in vacuo to give 4-(2-naphthyloxy)phenyl isocyanate (4.1 g) as a fraction boiling at 137° to 149° C./0.8 mmHg. M.P., 75°-77° C.

후처리

  1. temperaturethe resulting mixture was refluxed for 1 hour
  2. customAfter removal of the solvent from the reaction mixture
  3. distillationby distillation under reduced pressure
  4. distillationthe residue was distilled in vacuo

출처 및 근거

ORD 기록
ord-2b1e183f6c204dbf8588190f1b98d0ab
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04280835

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