2-Amino-5-bromopyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

HRID 1278187노트

반응식

HRID 1278187 반응식
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([O:9]C1C=CC([N+]([O-])=O)=CC=1)=O)=[O:5].[Br:24][C:25]1[CH:26]=[CH:27][C:28]([NH2:31])=[N:29][CH:30]=1>>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([NH:31][C:28]1[CH:27]=[CH:26][C:25]([Br:24])=[CH:30][N:29]=1)=[O:9])=[O:5]

참가 물질

3

반응물 2

HCID 706222-Amino-5-bromopyridineHCID 570409802-Chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester

생성물 1

HCID 130230741-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

실험 절차

To a solution of 2-chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester, in an inert organic solvent is added 5-bromo-2-aminopyridine. The reaction mixture is stirred at an elevated temperature for a period of time, and is then evaporated to dryness under vacuum. The product named in the heading above, identical to the product of Example 2, is isolated and purified by recrystallization.

후처리

  1. customis then evaporated to dryness under vacuum
  2. customis isolated
  3. custompurified by recrystallization

출처 및 근거

ORD 기록
ord-f41619048b9f44fe984c3c1b1e1bfa8c
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04281003

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