Dimethylformamide → 7-(3-Pyridyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

반응식

Br[C:2]1[CH:3]=[N:4][N:5]2[C:10]([C:11]3[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=3)=[CH:9][CH:8]=[N:7][C:6]=12.[CH3:17][N:18](C)C=O>>[N:13]1[CH:14]=[CH:15][CH:16]=[C:11]([C:10]2[N:5]3[N:4]=[CH:3][C:2]([C:17]#[N:18])=[C:6]3[N:7]=[CH:8][CH:9]=2)[CH:12]=1

참가 물질

반응물 2

HCID 6228Dimethylformamide

HCID 12766251HCID 12766251, 화합물

생성물 1

HCID 112183037-(3-Pyridyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

실험 절차

A mixture of 1.0 g. of 3-bromo-7-(3-pyridyl)pyrazolo[1,5-a]pyrimidine and 0.50 g. of cuprous cyanide in 25 ml. of N,N-dimethylformamide is heated at reflux temperature for 16 hours. The solvent is removed in vacuo and the residue is triturated with dichloromethane. The dichloromethane solution is passed through a column of hydrous magnesium silicate. The eluent is concentrated and hexane added to give the product of the example as tan crystals, m.p. 258°-260° C.

후처리

additionA mixture of 1.0 g
temperatureat reflux temperature for 16 hours
customThe solvent is removed in vacuo
customthe residue is triturated with dichloromethane
concentrationThe eluent is concentrated
additionhexane added
customto give the product of the example as tan crystals, m.p. 258°-260° C.

출처 및 근거

ORD 기록: ord-fc8f06349240457799d107996b6f3c56
출처 데이터셋: uspto-grants-1981_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04281000

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