1-Chlorobenzotriazole → HCID 11299190, 화합물

HRID 1278223노트

반응식

HRID 1278223 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][CH:15]=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[Cl:16]N1C2C=CC=CC=2N=N1>ClCCl>[Cl:16][C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[CH:8][CH:9]=[N:10][C:11]=12

참가 물질

4

반응물 2

HCID 887611-ChlorobenzotriazoleHCID 11206374HCID 11206374, 화합물

생성물 1

HCID 11299190HCID 11299190, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 3.92 g. of 7-(3-pyridyl)pyrazolo[1,5-a]-pyrimidine and 3.40 g. of N-chlorobenzotriazole in 100 ml. of dichloromethane is heated on a steam bath for 15 minutes. The mixture is poured into 100 ml. of ice cold 2.5 N sodium hydroxide and the dichloromethane layer is separated and dried over anhydrous sodium sulfate. The dichloromethane extract is passed through a column of hydrous magnesium silicate and the eluent is concentrated and diluted with hexane to give 2.75 g. of the product of the example, m.p. 225°-226° C.

후처리

  1. additionA mixture of 3.92 g
  2. additionThe mixture is poured into 100 ml
  3. customof ice cold 2.5 N sodium hydroxide and the dichloromethane layer is separated
  4. dry with materialdried over anhydrous sodium sulfate
  5. extractionThe dichloromethane extract
  6. concentrationthe eluent is concentrated
  7. additiondiluted with hexane
  8. customto give 2.75 g

출처 및 근거

ORD 기록
ord-ab6a0ac92f9e4ee9aa8abd728e46c622
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04281000

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