Phosphate → 3-Phenylacetamido-4-(2-hydroxyethyl)-2-azetidinone

HRID 1278251노트

반응식

HRID 1278251 반응식
O1CCCCC1[N:7]1[CH:10]([CH2:11][CH2:12][O:13]C2CCCCO2)[CH:9]([NH:20][C:21](=[O:29])[CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:8]1=[O:30].O.C1(C)C=CC(S(O)(=O)=O)=CC=1.P([O-])([O-])([O-])=O>CO>[C:23]1([CH2:22][C:21]([NH:20][CH:9]2[CH:10]([CH2:11][CH2:12][OH:13])[NH:7][C:8]2=[O:30])=[O:29])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

참가 물질

5

반응물 3

HCID 1061PhosphateHCID 521998p-Toluenesulfonic acid monohydrateHCID 541458371-(2-Tetrahydropyranyl)-3-phenylacetamido-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinone

생성물 1

HCID 128047363-Phenylacetamido-4-(2-hydroxyethyl)-2-azetidinone

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1-(2-tetrahydropyranyl)-3-phenylacetamido-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinone in methanol at 25° C. is treated with 0.1 molar equivalent of p-toluenesulfonic acid monohydrate. The solution is stirred for a period of 2 hours and then neutralized with 1 M pH 7 phosphate buffer. The product is extracted into ethyl acetate. The ethyl acetate solution is washed with brine, dried over magnesium sulfate and filtered. The filtrate is evaporated under reduced pressure to give 3-phenylacetamido-4-(2-hydroxyethyl)-2-azetidinone.

후처리

  1. extractionThe product is extracted into ethyl acetate
  2. washThe ethyl acetate solution is washed with brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customThe filtrate is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-a839712fa29b4df5a4f5d89a74e04615
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04281002

반응 노트

불러오는 중…