Lactulose → Lactitol dihydrate

HRID 1278523

반응식

HRID 1278523 반응식
[CH2:1]([OH:23])[C@H:2]1[O:7][C@@H:6]([O:8][C@H:9]2[C@H:13]([OH:14])[C@@:12]([OH:17])([CH2:15][OH:16])[O:11][C@@H:10]2[CH2:18][OH:19])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@H:3]1[OH:22]>O>[CH2:1]([OH:23])[C@H:2]1[O:7][C@@H:6]([O:8][C@@H:9]([C@H:13]([OH:14])[C@@H:12]([OH:17])[CH2:15][OH:16])[C@H:10]([OH:11])[CH2:18][OH:19])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@H:3]1[OH:22].[OH2:7].[CH2:1]([OH:23])[C@H:2]1[O:7][C@@H:6]([O:8][C@@H:9]([C@H:13]([OH:14])[C@@H:12]([OH:17])[CH2:15][OH:16])[C@H:10]([OH:11])[CH2:18][OH:19])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@H:3]1[OH:22].[OH2:7].[OH2:7]

참가 물질

4

반응물 1

HCID 11333Lactulose4회

생성물 2

HCID 157354Lactitol dihydrateHCID 3067270Lactitol Monohydrate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Because the mixture according to the invention is a liquid, it is preferable to start from the lactitol reaction mixture obtained after the hydrogenation of lactose. Said reaction is usually performed in an aqueous medium in the presence of a suitable hydrogenation catalyst. The lactitol solution in water obtained after filtration, purification and possibly concentration by evaporation is very suitable as a source of lactitol for the preparation of the mixture according to the invention. The condition for using such a solution is, however, that the lactitol solution is sufficiently pure, that is to say at least 90% by weight, and preferably 95% by weight, of the content of dissolved solids is composed of lactitol. The advantage of using such a lactitol is that no crystallization step is necessary to obtain crystalline lactitol monohydrate or crystalline lactitol dihydrate which then has to be redissolved. The advantage of using a crystalline lactitol hydrate is the high purity (usually more than 97% by weight of lactitol).

후처리

  1. customreaction
  2. filtrationafter filtration, purification and possibly concentration
  3. customby evaporation
  4. customis very suitable as a source of lactitol for the preparation of the mixture
  5. customis that no crystallization step

출처 및 근거

ORD 기록
ord-2a5e4ca8d1144f40a279578c97fc92b7
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06444250B1

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