Dicyclohexylcarbodiimide → N-[(Phenylmethoxy)carbonyl]-L-leucine 2,5-dioxo-1-pyrrolidinyl ester

HRID 1278535노트

반응식

HRID 1278535 반응식
[NH:1]([C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11])[C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].O[N:21]1[C:25](=[O:26])[CH2:24][CH2:23][C:22]1=[O:27].C1CCC(N=C=NC2CCCCC2)CC1>O1CCOCC1>[NH:1]([C:10]([O:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:11])[C@H:2]([C:7]([O:9][N:21]1[C:25](=[O:26])[CH2:24][CH2:23][C:22]1=[O:27])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]

참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 74840Leucine, N-carboxy-, N-benzyl ester, L-HCID 80170N-Hydroxysuccinimide

생성물 1

HCID 11089751N-[(Phenylmethoxy)carbonyl]-L-leucine 2,5-dioxo-1-pyrrolidinyl ester

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
0 °C

실험 절차

Z-Leu-OH (15.92 g) and N-hydroxysuccinimide (6.9 g) were dissolved in dioxane and cooled to 0° C. To the cooled solution, DCC was added and stirred at 0° C. for 0.5 h, then room temp overnight. After filtering off the by product urea, the filtrate was concentrated to give crude Z-Leu-OSu as an oil.

후처리

  1. customroom temp overnight
  2. filtrationAfter filtering off the by product urea
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-50ed8676e59b4303ac12615785994467
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06444457B1

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