Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → Ethyl 3-phenyl-5-trimethylsilanylpent-2-en-4-ynoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Trimethylsilylacetylene | HCID 66111 | — |
| 반응물 | Phenylpropynoic acid methyl ester | HCID 138378 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 생성물 | Ethyl 3-phenyl-5-trimethylsilanylpent-2-en-4-ynoate | HCID 86142661 | — |
반응 단계
A solution of TDMPP (1.4 g) and palladium acetate (700 mg) in THF (200 ml) is stirred for 15 min at room temperature and methyl phenylpropiolate (10 g, 62.5 mmol) is then added. The reaction medium is stirred for 5 min at room temperature and trimethylsilylacetylene (87.5 mmol) is then added. Stirring is continued overnight at room temperature. The reaction medium is concentrated and filtered through silica.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06444709B1 |
| 출처 데이터셋 | uspto-grants-2002_09 |
| ORD ID | ord-7717bc734c1f4d6da17da5227d18228c |
| 출처 메모 | uspto-grants-2002_09 |