2-tert-Butyl-1,3-diisopropylisourea → tert-Butyl 3-bromo-2-oxobutanoate

HRID 127889

반응식

HRID 127889 반응식
[Br:1][CH:2]([CH3:8])[C:3](=[O:7])[C:4]([OH:6])=[O:5].[C:9](OC(=NC(C)C)NC(C)C)([CH3:12])([CH3:11])[CH3:10]>C(Cl)Cl>[Br:1][CH:2]([CH3:8])[C:3](=[O:7])[C:4]([O:6][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:5]

참가 물질

4

반응물 2

HCID 110417822-tert-Butyl-1,3-diisopropylisoureaHCID 144712563-Bromo-2-oxobutanoic acid

생성물 1

HCID 23470149tert-Butyl 3-bromo-2-oxobutanoate수율 47.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 1.6 g (8.85 mmol) of 3-bromo-2-ketobutyric acid and 7 g (4 equivalents) of O-t-butyl-N,N'-diisopropylpseudourea in 14 ml methylene chloride is stirred overnight at room temperature. After filtration, the solution is washed with NaHCO3 and brine, dried and evaporated to an oil which is chromatographed on silica gel with benzene as eluant to give 1 g (45%) of t-butyl 3-bromo-2-ketobutyrate.

후처리

  1. filtrationAfter filtration
  2. washthe solution is washed with NaHCO3 and brine
  3. customdried
  4. customevaporated to an oil which
  5. customis chromatographed on silica gel with benzene as eluant

출처 및 근거

ORD 기록
ord-c830d3d5ac4f43b8a99b12c1711f57cb
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04257947

연결된 노트

불러오는 중…