Potassium Carbonate → 2-bromo-4-methyl-6-(3-trifluoromethyl-1H-pyrazol-1-yl)-pyridine

HRID 1279181노트

반응식

HRID 1279181 반응식
Br[C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([Br:9])[N:3]=1.[F:10][C:11]([F:18])([F:17])[C:12]1[CH:16]=[CH:15][NH:14][N:13]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:9][C:4]1[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([N:14]2[CH:15]=[CH:16][C:12]([C:11]([F:18])([F:17])[F:10])=[N:13]2)[N:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 18070343-(Trifluoromethyl)pyrazoleHCID 112881742,6-Dibromo-4-methylpyridine

생성물 1

HCID 184272852-bromo-4-methyl-6-(3-trifluoromethyl-1H-pyrazol-1-yl)-pyridine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

A mixture of 2,6-dibromo-4-methylpyridine (33 mmol, obtained according to the method disclosed by WO 94/22833), 3-trifluoromethyl-1H-pyrazole (21 mmol), potassium carbonate (45 mmol) and N,N-dimethylformamide ((50 mL) is heated at 90° C. for 4 hours. The reaction mixture is partitioned between ethyl acetate ands water. The separated organic phase is washed with brine, dried over sodium sulfate and evaporated in vacuo to provide an oily residue which is purified by flash chromatography. To yield 1.9 g of the title compound.

후처리

  1. customobtained
  2. customThe reaction mixture is partitioned between ethyl acetate ands water
  3. washThe separated organic phase is washed with brine
  4. dry with materialdried over sodium sulfate
  5. customevaporated in vacuo
  6. customto provide an oily residue which
  7. customis purified by flash chromatography

출처 및 근거

ORD 기록
ord-0b70f3c3691540a69001dd9e0d525ece
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06448204B1

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