Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphane dichloride → 7-Chloro-4-methylisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphane dichloride | HCID 13797396 | — |
| 반응물 | 4-Methylisoquinolin-7-ol | HCID 20523221 | — |
| 생성물 | 7-Chloro-4-methylisoquinoline | HCID 20523223 | — |
반응 단계
A mixture of 15.9 g. (0.1 mole) of 7-hydroxy-4-methylisoquinoline and 41.7 g. (0.125 mole) of triphenylphosphine dichloride is heated to 230° C. for four hours, cooled, and partitioned between chloroform and concentrated hydrochloric acid. The aqueous phase is neutralized with ammonium hydroxide and extracted with chloroform to yield 7-chloro-4-methylisoquinoline.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04258049 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-c0cea5daa3b4421f915baefa854521fa |
| 출처 메모 | uspto-grants-1981_03 |