Potassium Hydroxide → HCID 15571589, 화합물

HRID 127926노트

반응식

HRID 127926 반응식
Cl.[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([OH:19])[CH:12]=2)=[CH:5][N:4]=1.Br[CH2:21][CH2:22][NH:23][S:24](=[O:36])([C:26]1[CH:31]=[CH:30][C:29]([NH:32][C:33](=[O:35])[CH3:34])=[CH:28][CH:27]=1)=[O:25].[OH-].[K+]>CO>[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH2:21][CH2:22][NH:23][S:24](=[O:36])([C:26]3[CH:27]=[CH:28][C:29]([NH:32][C:33](=[O:35])[CH3:34])=[CH:30][CH:31]=3)=[O:25])[CH:12]=2)=[CH:5][N:4]=1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 4469766HCID 4469766, 화합물HCID 15571588HCID 15571588, 화합물

생성물 1

HCID 15571589HCID 15571589, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 1.41 g (0.005 mole) of 2,4-diamino-5-(3'-hydroxy-4'-methoxybenzyl)pyrimidine hydrochloride, 2.0 g (0.00625 mole) of N1 -(2-bromoethyl)-N4 -acetylsulfanilamide, 25 ml of methanol, and 6.0 ml of an aqueous solution containing 0.013 mole of potassium hydroxide is heated at reflux for 1.5 hr.

후처리

  1. temperatureis heated
  2. temperatureat reflux for 1.5 hr

출처 및 근거

ORD 기록
ord-2079959d162443efae16c592e6961ca2
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04258045

반응 노트

불러오는 중…