Ethylamine → 1-Ethyl-2-methoxymethyl-3-benzyloxy-6-methyl-pyridin-4(1H)-one hydrochloride

반응식

[ClH:1].[CH3:2][N:3]1[C:8]([CH3:9])=[CH:7][C:6](=[O:10])[C:5]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:4]1[CH2:19][O:20][CH3:21].[CH3:22]OCC1OC(C)=CC(=O)C=1OCC1C=CC=CC=1.C(N)C>>[ClH:1].[CH2:2]([N:3]1[C:8]([CH3:9])=[CH:7][C:6](=[O:10])[C:5]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:4]1[CH2:19][O:20][CH3:21])[CH3:22]

참가 물질

반응물 3

HCID 6341Ethylamine

HCID 117473362-methoxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one

HCID 699544351,6-Dimethyl-2-methoxymethyl-3-benzyloxypyridin-4(1H)-one hydrochloride

생성물 1

HCID 186787941-Ethyl-2-methoxymethyl-3-benzyloxy-6-methyl-pyridin-4(1H)-one hydrochloride

실험 절차

The title compound was prepared by the method outlined for 1,6-dimethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one hydrochloride, using 6.5 g (25 mmol, 1 eq.) of 2-(1-methoxymethyl)-3-benzyloxy-6-methyl-pyran-4(1H)-one and 4.82 g (75 mmol, 3 eq.) of 70% aqueous ethylamine to yield the pure product 3.7 g (45.7%/) after recrystallisation from methanol/diethyl ether, as a white crystalline solid m.p. 114-116° C.