N-(4-Chloro-2-nitrophenyl)benzenesulfonamide → 2-Phenylsulfonylamino-5-chloroaniline

HRID 1279600

반응식

HRID 1279600 반응식
[C:1]1([S:7]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[N+:18]([O-])=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)(=O)C.C(OCC)(=O)C>[C:1]1([S:7]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[NH2:18])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 1

HCID 555628N-(4-Chloro-2-nitrophenyl)benzenesulfonamide

생성물 1

HCID 130413992-Phenylsulfonylamino-5-chloroaniline수율 59.2%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 8857Ethyl Acetate용매

반응 조건

온도
120 °C

실험 절차

To a solution of 2-phenylsulfonylamino-5-chloro-1-nitrobenzene (172 mg; prepared in Reference Example 11.) in acetic acid (4 ml), reduced iron powder (154 mg) was added at room temperature under an atmosphere of argon. The suspension was stirred for 2 hours at 120° C. The reaction suspension was diluted with ethyl acetate and filtered. The filtrate was concentrated under the reduced pressure. The residue was purified on silica gel column chromatography (AcOEt-hexane) to give the title compound (92 mg) having the following physical data.

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated under the reduced pressure
  3. customThe residue was purified on silica gel column chromatography (AcOEt-hexane)

출처 및 근거

ORD 기록
ord-9779766ede174381925a943624cd1cf4
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06448290B1

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