Thionyl Chloride → 2,4-Pentadienoyl chloride, 5-phenyl-

HRID 1279676노트

반응식

HRID 1279676 반응식
[CH:1](=[CH:10][C:11]([OH:13])=O)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.S(Cl)([Cl:16])=O>CCCCCC>[CH:1](=[CH:10][C:11]([Cl:16])=[O:13])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 737775-Phenyl-2,4-pentadienoic acid

생성물 1

HCID 30848092,4-Pentadienoyl chloride, 5-phenyl-수율 77.9%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Preparation of C6H5—CH═CH—CH═CH—CO2PEG-OCH2CH(OC2H5)2: A solution of cinnamylideneacetic acid (1.7 g, 0.01 moles) and thionyl chloride (3 ml, 0.04 moles) in 50 ml of hexane were refluxed under N2 for 4 h, then filtered to remove a small amount of dark solid and the filtrate evaporated under vacuum. The residue was dried under vacuum overnight at room temperature to obtain 1.5 g of cinnamylideneacetyl chloride as a yellow solid, m.p. 51-52° C.)

후처리

  1. customPreparation of C6H5—CH═CH—CH═CH—CO2PEG-OCH2CH(OC2H5)2
  2. filtrationfiltered
  3. customto remove a small amount of dark solid
  4. customthe filtrate evaporated under vacuum
  5. customThe residue was dried under vacuum overnight at room temperature

출처 및 근거

ORD 기록
ord-e9eb2f44eade41bca07f4eec3a20dde3
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06448369B1

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