Trifluoroacetic acid → HCID 59909816, 화합물

HRID 1279855노트

반응식

[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([O:6][CH2:7][C:8]2[N:12]=[C:11]([C@H:13]([CH2:22][CH2:23][CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])[O:10][N:9]=2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[N:12]=[C:11]([C@H:13]([CH2:22][CH2:23][CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][C:15]([OH:17])=[O:16])[O:10][N:9]=2)=[CH:31][CH:32]=1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 59909802HCID 59909802, 화합물

생성물 1

HCID 59909816HCID 59909816, 화합물수율 101%

실험 절차

tert-Butyl (3R)-3-{3-[(4-chlorophenoxy)methyl]-1,2,4-oxadiazol-5-yl}6-cyclohexylhexanoate (Preparation 56) (215 mg, 0.46 mmol) was treated with trifluoroacetic acid (5 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 4 hours. The solvent was removed under reduced pressure and the residue azeotroped from toluene to afford the title compound (189 mg).

후처리

customThe solvent was removed under reduced pressure
customthe residue azeotroped from toluene

출처 및 근거

ORD 기록: ord-a939e69104da4b938bbd532c30cdf3c5
출처 데이터셋: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06448278B2

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