5-Amino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-4-nitroso-pyrazole → 4,5-Diamino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-pyrazole

HRID 1280435노트

반응식

HRID 1280435 반응식
[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])[N:5]=[C:4]([C:15]2[O:16][C:17]([CH2:20][OH:21])=[CH:18][CH:19]=2)[C:3]=1[N:22]=O.[H][H]>C(O)C.[Pd]>[NH2:22][C:3]1[C:4]([C:15]2[O:16][C:17]([CH2:20][OH:21])=[CH:18][CH:19]=2)=[N:5][N:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])[C:2]=1[NH2:1]

참가 물질

5

반응물 2

HCID 120182125-Amino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-4-nitroso-pyrazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 120182134,5-Diamino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-pyrazole

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The compound from Example 5A (8 g) is dissolved in ethanol, treated with 0.5 g of 5% strength palladium on carbon and hydrogenated for 15 minutes in a Parr apparatus at a hydrogen pressure of 2 bar. The solution is filtered off with suction through kieselguhr and used for the next batch (Rf=0.21, T1E1, SiO2).

후처리

  1. filtrationThe solution is filtered off with suction through kieselguhr

출처 및 근거

ORD 기록
ord-7b096c78b4aa484ea3da298ce5dd0031
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06451805B1

반응 노트

불러오는 중…