Cadaverine → N-(5-Aminopentyl)benzamide

HRID 1280480

반응식

HRID 1280480 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[C:8](N)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

3

반응물 2

HCID 273CadaverineHCID 2331Benzamide

생성물 1

HCID 345353N-(5-Aminopentyl)benzamide수율 70.6%

실험 절차

Under an argon atmosphere, 1,5-diaminopentane (25 g, 0.24 mol) and benzamide (9.9 g, 0.081 mol) were combined and heated at reflux overnight. The reaction mixture was concentrated under vacuum to remove the excess diamine. The residue was distilled at about 210° C. at 12 torr (16×102 pascals) to provide 11.8 g of N-(5-aminopentyl)benzamide as a colorless oil.

후처리

  1. temperatureheated
  2. temperatureat reflux overnight
  3. concentrationThe reaction mixture was concentrated under vacuum
  4. customto remove the excess diamine
  5. distillationThe residue was distilled at about 210° C. at 12 torr (16×102 pascals)

출처 및 근거

ORD 기록
ord-fdef2ca9f7c841c5810dc4c526cd3584
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06451810B1

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