3,3-Dimethyl-12-isopropyl-1-aza-1,5,9-cyclododecatriene → 3,3-Dimethyl-12-isopropyl-1-aza-cyclododecene

HRID 128050

반응식

HRID 128050 반응식
[CH3:1][C:2]1([CH3:17])[CH2:13][CH:12]=[CH:11][CH2:10][CH2:9][CH:8]=[CH:7][CH2:6][CH:5]([CH:14]([CH3:16])[CH3:15])[N:4]=[CH:3]1>C1CCCCC1.[Rh].[O-2].[Al+3].[O-2].[O-2].[Al+3]>[CH3:1][C:2]1([CH3:17])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH:5]([CH:14]([CH3:15])[CH3:16])[N:4]=[CH:3]1

참가 물질

4

반응물 1

HCID 5575123,3-Dimethyl-12-isopropyl-1-aza-1,5,9-cyclododecatriene

생성물 1

HCID 204360973,3-Dimethyl-12-isopropyl-1-aza-cyclododecene수율 89.5%

시약·촉매·용매 2

HCID 131712135Rhodium aluminium oxide촉매HCID 8078Cyclohexane용매

실험 절차

466.8 g (2 mols) of 3,3-dimethyl-12-isopropyl-1-aza-1,5,9-cyclododecatriene is dissolved in 4 liters of cyclohexane, and the solution is hydrogenated at 20°-25° C. under an initial pressure of 100 bars, in the presence of 80 g of rhodium/aluminium oxide, for 4 hours in a steel autoclave. The solvent is then distilled off to obtain, as main fraction, 425 g (1.79 mols) of 3,3-dimethyl-12-isopropyl-1-aza-cyclododecene; b.p. 92°-94° C./4 Pa; nD20 =1.4706.

후처리

  1. customis hydrogenated at 20°-25° C.
  2. distillationThe solvent is then distilled off

출처 및 근거

ORD 기록
ord-09cff4e4817b49aeb56da15c1709e833
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04258176

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