1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine → n1-[2-(4-Amino-1h-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide

HRID 1280504

반응식

HRID 1280504 반응식
O[N:2]1[C:23](=[O:24])[NH:22][C@H:21]2[C@@H:3]1[CH2:4][S:5][C@H:6]2[CH2:7][CH2:8][CH2:9][CH:10](N1C(=O)CCC1=O)[C:11](=[O:13])O.[NH2:25][CH2:26][CH2:27][N:28]1[C:40]2[C:39]3[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=3[N:33]=[C:32]([NH2:41])[C:31]=2[N:30]=[CH:29]1>>[NH2:41][C:32]1[C:31]2[N:30]=[CH:29][N:28]([CH2:27][CH2:26][NH:25][C:11](=[O:13])[CH2:10][CH2:9][CH2:8][CH2:7][CH:6]3[CH:21]4[CH:3]([NH:2][C:23](=[O:24])[NH:22]4)[CH2:4][S:5]3)[C:40]=2[C:39]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=2[N:33]=1

참가 물질

3

반응물 2

HCID 235127191-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amineHCID 129676281N-Hydroxysuccinimido-d-biotin

생성물 1

HCID 23512652n1-[2-(4-Amino-1h-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide수율 75.2%

실험 절차

Using the general method of Example 24, N-hydroxysuccinimidobiotin (0.6 g, 1.76 mmol) was reacted with 1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine (0.4 g, 1.76 mmol) to provide 0.6 g of N1-[2-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide as a solid, m.p. 169° C.

출처 및 근거

ORD 기록
ord-a9d6237504f2476893d24b6538b61c58
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06451810B1

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