(RS)-4-(Pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid → (2RS,3SR)-2-{2-[3-(4-Hydroxy-benzenesulfonyl)-pyrrolidin-1-yl]-ethyl}-1,2,3,4-tetrahydro-naphthalen-2-ol
반응식
FC(F)(F)C(O)=O.[NH:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:9]1.Br[CH2:24][CH2:25][C:26]1([OH:36])[CH2:35][CH2:34][C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27]1>>[OH:22][C:19]1[CH:20]=[CH:21][C:16]([S:13]([CH:10]2[CH2:11][CH2:12][N:8]([CH2:24][CH2:25][C:26]3([OH:36])[CH2:35][CH2:34][C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:27]3)[CH2:9]2)(=[O:15])=[O:14])=[CH:17][CH:18]=1참가 물질
3
실험 절차
The title compound, MS: m/e=402.4 (M+H+) was prepared from (RS)-4-(pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid salt and (RS)-2-(2-bromo-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-ol.
출처 및 근거
- ORD 기록
- ord-bca09e4b14ea4d4da129eef6f473d4d7
- 출처 데이터셋
- uspto-grants-2002_09
- DOI