Aluminium lithium hydride → HCID 15936950, 화합물

HRID 1280740노트

반응식

HRID 1280740 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].C[O:8][C:9](=O)[CH:10]([F:19])[CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1COCC1>[F:19][CH:10]([CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][OH:8]

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 86584023HCID 86584023, 화합물

생성물 1

HCID 15936950HCID 15936950, 화합물수율 99.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
0 °C

실험 절차

To a 0° C. suspension of LiAlH4 (0.4 g, 10.6 mmol) in dry THF (5 ml) was added dropwise a solution of (RS)-2-fluoro-4-phenyl-butyric acid methyl ester (1 g, 5.3 mmol) in dry THF (10 ml). After 1 hour stirring at 0° C., the reaction mixture was quenched successively with H2O (0.4 ml), 5N NaOH (0.4 ml) and again H2O (1.2 ml). The resulting solid was filtered and the filtrate was concentrated to provide (RS)-2-fluoro-4-phenyl-butan-1-ol (0.89 g, 99%) as a colorless oil, MS: m/e=168.1 (M+).

후처리

  1. customthe reaction mixture was quenched successively with H2O (0.4 ml), 5N NaOH (0.4 ml) and again H2O (1.2 ml)
  2. filtrationThe resulting solid was filtered
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-9efcf73044344bba87983126c711ab7b
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06451819B2

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