Potassium Hydroxide → HCID 9812939, 화합물

HRID 1280756노트

반응식

HRID 1280756 반응식
C[O:2][C:3](=[O:14])[CH:4]([F:13])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[OH-].[K+]>CCO>[F:13][CH:4]([CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([OH:14])=[O:2]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 86584023HCID 86584023, 화합물

생성물 1

HCID 9812939HCID 9812939, 화합물수율 94.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

(RS)-2-Fluoro-4-phenyl-butyric acid methyl ester (0.39 g, 2 mmol) was added to a solution of KOH (0.56 g, 10 mmol) in EtOH (5 ml). After 1 hour stirring at room temperature. the reaction mixture was concentrated, diluted with H2O (5 ml), acidified to pH 1 with 2N HCl and extracted with CH2Cl2 (3 times). The combined organic phases were dried over Na2SO4, filtered and concentrated to provide (RS)-2-fluoro-4-phenyl-butyric acid (0.343 g, 92%) as a colorless oil MS: m/e=182.1 (M+).

후처리

  1. concentrationthe reaction mixture was concentrated
  2. additiondiluted with H2O (5 ml)
  3. extractionextracted with CH2Cl2 (3 times)
  4. dry with materialThe combined organic phases were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-feddb2f020bd44029ef12e29a1914a5a
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06451819B2

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