참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hippuric Acid | HCID 464 | — |
| 반응물 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 반응물 | 1-(4-Chlorobenzyl)pyrrolidin-3-amine dihydrochloride | HCID 18426180 | — |
| 반응물 | Dimethylaminopropyl carbodiimide hydrochloride | HCID 21899179 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 3-(N-benzoylglycyl)amino-1-(4-chlorobenzyl)pyrrolidine | HCID 9842404 | — |
반응 단계
N-Benzoylglycine (9.9 mg, 0.055 mmol), 3-ethyl-1-(3-(dimethylaminopropyl)carbodiimide hydrochloride (EDCI) (10.5 mg) and 1-hydroxybenzotriazole hydrate (HOBt) (7.4 mg) were added to a solution of 3-amino-1-(4-chlorobenzyl)pyrrolidine dihydrochloride (14.2 mg, 0.050 mmol) and Et3N (15.2 mg) in CHCl3 (2.5 mL). The reaction mixture was stirred at 25° C. for 16 h, washed with 2 N aqueous NaOH (2 mL×2) and brine (1 mL). After filtration through a PTFE membrane filter, the solvent was removed under reduced pressure to afford 3-(N-benzoylglycyl)amino-1-(4-chlorobenzyl)pyrrolidine (compound No. 1) as a pale yellow oil (17.7 mg, 95%): The purity was determined by RPLC/MS (95%); ESI/MS m/e 372.0 (M++H, C20H22ClN3O2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06451842B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_09 |
|---|
| ORD ID | ord-dcc9b4670f1e4ec1a467bc1e330e69da |
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| 출처 메모 | uspto-grants-2002_09 |
|---|
