반응식
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:39]=[CH:38][C:37]([C:40]([F:43])([F:42])[F:41])=[CH:36][C:10]=1[C:11]([NH:13][CH2:14][C:15]([NH:17][C@@H:18]1[CH2:22][CH2:21][N:20]([CH2:23][C:24]2[CH:29]=[C:28]3[O:30][CH2:31][O:32][C:27]3=[CH:26][C:25]=2[N+:33]([O-])=O)[CH2:19]1)=[O:16])=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].CO>[NH2:33][C:25]1[CH:26]=[C:27]2[O:32][CH2:31][O:30][C:28]2=[CH:29][C:24]=1[CH2:23][N:20]1[CH2:21][CH2:22][C@@H:18]([NH:17][C:15](=[O:16])[CH2:14][NH:13][C:11](=[O:12])[C:10]2[CH:36]=[C:37]([C:40]([F:43])([F:41])[F:42])[CH:38]=[CH:39][C:9]=2[NH:8][C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[CH2:19]1참가 물질
4
반응물 1
생성물 1
시약·촉매·용매 2
실험 절차
A mixture of (R)-3-[{N-(2-(tert-butoxycarbonylamino)-5-trifluoromethylbenzoyl)glycyl}amino]-1-(4,5-methylenedioxy-2-nitrobenzyl)pyrrolidine prepared above, 10% Pd-activated carbone (22 mg), and methanol (3.0 mL) was stirred under a hydrogen atmosphere at room temperature overnight. The Pd catalyst was filtered off, and the filtrate was concentrated to afford (R)-1-(2-amino-4,5-methylenedioxybenzyl)-3-[{N-(2-(tert-butoxycarbonylamino)-5-trifluoromethylbenzoyl)glycyl}amino]pyrrolidine (87.1 mg, quant.): Any remarkable by-products were not detected in TLC.
후처리
- filtrationThe Pd catalyst was filtered off
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-d7f7e7d9c1074ee386961e611bbb59c7
- 출처 데이터셋
- uspto-grants-2002_09
- 특허 번호
- US06451842B1
연결된 노트
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