Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1280974생성일: 2026년 10월 24일
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 2-((N-benzoylleucyl)aminomethyl)-1-(4-chlorobenzyl)pyrrolidine
https://huagongshe.com/ko/reaction/1280974
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Benzoyl-L-leucine | HCID 853887 | — |
| 반응물 | 2-(Aminomethyl)-1-(4-chlorobenzyl)pyrrolidine | HCID 14709036 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 2-((N-benzoylleucyl)aminomethyl)-1-(4-chlorobenzyl)pyrrolidine | HCID 53639429 | — |
반응 단계
A solution of 2-(aminomethyl)-1-(4-chlorobenzyl)pyrrolidine (22.5 mg, 0.10 mmol) and dl-benzoylleucine (0.12 mmol) in CHCl3 (1 mL) was treated with EDCI (23 mg), HOBt (16.2 mg) and Et3N (15.2 μL), and stirred at 25° C. for 16 h. The reaction mixture was diluted with CH2Cl2 (0.5 mL), washed with 2 N aqueous NaOH solution (2×0.75 mL), dried by filtration through a PTFE membrane and concentrated to afford 2-{(N-benzoylleucyl)aminomethyl}-1-(4-chlorobenzyl)pyrrolidine (compound No. 344) (74 mg, quant): The purity was determined by RPLC/MS (85%); ESI/MS m/e 442 (M++H, C25H32ClN3O2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06451842B1 |
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| 출처 데이터셋 | uspto-grants-2002_09 |
|---|
| ORD ID | ord-8a0de64a23794320bf34e4ed8f6f384a |
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| 출처 메모 | uspto-grants-2002_09 |
|---|
