3-(Dimethylamino)-8-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazole → 3-(Dimethylamino)-8-hydroxymethyl-1,2,3,4-tetrahydrocarbazole

HRID 128112노트

반응식

HRID 128112 반응식
[CH3:1][N:2]([CH3:21])[CH:3]1[CH2:15][C:14]2[C:13]3[C:8](=[C:9]([C:16](OCC)=[O:17])[CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH2:5][CH2:4]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][N:2]([CH3:21])[CH:3]1[CH2:15][C:14]2[C:13]3[C:8](=[C:9]([CH2:16][OH:17])[CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH2:5][CH2:4]1

참가 물질

4

반응물 2

HCID 128917873-(Dimethylamino)-8-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazoleHCID 21226445Aluminium lithium hydride

생성물 1

HCID 128918683-(Dimethylamino)-8-hydroxymethyl-1,2,3,4-tetrahydrocarbazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Following a procedure similar to that described in Example 55 and using 2.4 g. of 3-(dimethylamino)-8-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazole (Example 44), 1,6 g. of lithium aluminum hydride and 150 ml. of dry tetrahydrofuran there was obtained, after successive recrystallizations from isopropyl alcohol and ethyl alcohol, 0.56 g. of 3-(dimethylamino)8-hydroxymethyl-1,2,3,4-tetrahydrocarbazole, m.p. 227°-230° C.

후처리

  1. customafter successive recrystallizations from isopropyl alcohol and ethyl alcohol, 0.56 g

출처 및 근거

ORD 기록
ord-0ca5219b982e4b47b26d1999badcaf9d
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04257952

반응 노트

불러오는 중…