참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Fluorobenzaldehyde | HCID 68023 | — |
| 반응물 | 5,6-Dichloro-1H-benzimidazole | HCID 331775 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 5,6-Dicloro-1-(4-formylphenyl)benzimidazole | HCID 18426862 | 62% |
반응 단계
A mixture of 5,6-dichlorobenzimidazole (94 mg, 0.50 mmol), 4-fluorobenzaldehyde (0.064 mL, 0.60 mmol), and potassium carbonate (83 mg, 0.60 mmol) in dimethylsulfoxide (3 mL) was heated at 100° C. for 3 h. The mixture was cooled to room temperature, and water was added. The precipitated product was collected by filtration and washed with water and ethanol to afford 5,6-dicloro-1-(4-formylphenyl)benzimidazole (90 mg, 62%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06452014B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_09 |
|---|
| ORD ID | ord-77e0a820f50b4273b184d09f2092f214 |
|---|
| 출처 메모 | uspto-grants-2002_09 |
|---|
