Ethanol → HCID 12874074, 화합물

HRID 128117노트

반응식

HRID 128117 반응식
Cl.[CH3:2][N:3]([CH3:11])[CH:4]1[CH2:9][CH2:8][C:7](=O)[CH2:6][CH2:5]1.Cl.[CH2:13]([O:20][C:21]1[CH:22]=[C:23]([NH:27]N)[CH:24]=[CH:25][CH:26]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(O)C>O>[CH3:2][N:3]([CH3:11])[CH:4]1[CH2:9][C:8]2[C:24]3[C:23](=[CH:22][C:21]([O:20][CH2:13][C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=4)=[CH:26][CH:25]=3)[NH:27][C:7]=2[CH2:6][CH2:5]1

참가 물질

5

반응물 3

HCID 702EthanolHCID 127174484-(Dimethylamino)cyclohexan-1-one--hydrogen chloride (1/1)HCID 12891839(3-(Benzyloxy)phenyl)hydrazine hydrochloride

생성물 1

HCID 12874074HCID 12874074, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 15.8 g. of 4-dimethylaminocyclohexanone hydrochloride and 20.3 g. of 3-benzyloxyphenylhydrazine hydrochloride (m.p. 165°-168° C.) in 225 ml. of absolute ethyl alcohol was heated under reflux for three hours, cooled to room temperature, and diluted with 50 ml. of water. After standing for three hours the resulting crystals were collected by filtration and washed with ethyl alcohol to give, after recrystallization from ethyl alcohol, 6.1 g. of 3-(dimethylamino)-7-(benzyloxy)-1,2,3,4-tetrahydrocarbazole hydrochloride, m.p. 237°-239° C.

후처리

  1. temperatureunder reflux for three hours
  2. additiondiluted with 50 ml
  3. filtrationthe resulting crystals were collected by filtration
  4. washwashed with ethyl alcohol
  5. customto give
  6. customafter recrystallization from ethyl alcohol, 6.1 g

출처 및 근거

ORD 기록
ord-f540a197607b4883af2442ebcef03c61
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04257952

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