Potassium Carbonate → 3-Cyclopentyloxy-4-methoxybenzaldehyde

HRID 1281179

반응식

HRID 1281179 반응식
[CH:1]1(Cl)[CH2:5][CH2:4][CH2:3][CH2:2]1.[O:7]=[CH:8][C:9]1[CH:17]=[CH:16][C:13]([O:14][CH3:15])=[C:11]([OH:12])[CH:10]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH:1]1([O:12][C:11]2[CH:10]=[C:9]([CH:17]=[CH:16][C:13]=2[O:14][CH3:15])[CH:8]=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 12127Isovanillin2회HCID 70252Chlorocyclopentane

생성물 1

HCID 27358933-Cyclopentyloxy-4-methoxybenzaldehyde

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
122.5 °C

실험 절차

A mixture of cyclopentyl chloride (8.48 g, 0.08 moles), isovanillin (6.12 g, 0.04 moles) and potassium carbonate (1.1 g, 0.08 moles) in dimethylformamide (4.04 g) was stirred in the reactor (100 mL) at 120 to 125° C. for 1.5 hours. A sample was taken to verify the batch conversion. Result (GC): 0.5 area % isovanillin (target:≦1.0 area %). The mixture was cooled to 20° C. and filtered to remove the solid (potassium bicarbonate, potassium chloride). The wet cake was washed with methanol.

후처리

  1. customResult (GC)
  2. temperatureThe mixture was cooled to 20° C.
  3. filtrationfiltered
  4. customto remove the solid (potassium bicarbonate, potassium chloride)
  5. washThe wet cake was washed with methanol

출처 및 근거

ORD 기록
ord-18e169bec6dc48c3b09d02436c189918
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06452022B1

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