Ethanol → tert-Butyl methylsulfonyl{3-[(2S)oxiranylmethoxy]phenyl}carbamate

HRID 1281479노트

반응식

HRID 1281479 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([N:15]([S:23]([CH3:26])(=[O:25])=[O:24])[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH:12]=[CH:13][CH:14]=1)[C:2]1C=CC=C[CH:3]=1.C1CCCCC=1.C([OH:35])C>[Pd]>[CH3:26][S:23]([N:15]([C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:1][C@@H:2]2[CH2:3][O:35]2)[CH:10]=1)[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:19])[CH3:20])(=[O:25])=[O:24]

참가 물질

5

반응물 3

HCID 702EthanolHCID 8079CyclohexeneHCID 53881295tert-Butyl 3-(benzyloxy)phenyl(methylsulfonyl)carbamate

생성물 1

HCID 23381355tert-Butyl methylsulfonyl{3-[(2S)oxiranylmethoxy]phenyl}carbamate

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

tert-Butyl 3-(benzyloxy)phenyl(methylsulfonyl)carbamate (2.6 g, 6.88 mmol) was dissolved in ethanol (25 mL), 10% palladium on carbon (0.75 g) and cyclohexene (1.5 mL) were added. The solution was heated to reflux for 3 hours. The solution was cooled and filtered through Celite. The solvent was removed in vacuo to yield crude title compound (1.93 g, 6.7 mmol).

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux for 3 hours
  3. temperatureThe solution was cooled
  4. filtrationfiltered through Celite
  5. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-b4813161adfa40088af585cb40d6459f
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06451814B1

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