Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 4-Methoxybenzoylacetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Bromomethyl 4-methoxyphenyl ketone | HCID 4965 | — |
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Methoxybenzoylacetonitrile | HCID 233398 | — |
반응 단계
A 25.0 g. portion of α-bromo-p-methoxyacetophenone is suspended in 125 ml. of ethanol. A solution of 16.0 g. of sodium cyanide in 75 ml. of water is added, using an ice-water bath to keep the temperature at 25°-30° C. The mixture is stirred for 45 minutes at room temperature. A total of 1.2 liters of water is added in 200 ml. increments with filtration through celite until no more precipitate forms. The filtrate is acidified to pH 5 with acetic acid. The solid is collected, washed with water, dried and recrystallized from benzene giving p-methoxybenzoylacetonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04259256 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-16bcd28ed9d6423b87ecfbe629b634ca |
| 출처 메모 | uspto-grants-1981_03 |