Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Anisole → 8,9-difluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Anisole | HCID 7519 | — |
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | Ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422150 | — |
| 촉매 | Titanium Tetrachloride | HCID 24193 | — |
| 생성물 | 8,9-difluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine | HCID 135816405 | — |
반응 단계
In the same manner as in Example 1 and using ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate, 1-methylpiperazine, anisole and titanium tetrachloride, 8,9-difluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06455521B1 |
| 출처 데이터셋 | uspto-grants-2002_09 |
| ORD ID | ord-d53b12cb02f146048619f630e18c4ca8 |
| 출처 메모 | uspto-grants-2002_09 |