Trifluoroacetic acid → 4-Aminonicotinic acid

HRID 1281924

반응식

HRID 1281924 반응식
C(OC([NH:8][C:9]1[C:14]([C:15]([OH:17])=[O:16])=[CH:13][N:12]=[CH:11][CH:10]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][C:9]1[C:14]([C:15]([OH:17])=[O:16])=[CH:13][N:12]=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 221726234-{[(Tert-butoxy)carbonyl]amino}pyridine-3-carboxylic acid

생성물 1

HCID 3199794-Aminonicotinic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 4-(N-t-butoxycarbonylamino)nicotinic acid (2.72 g, 11.4 mmol), TFA (10 mL), and CH2Cl2 (20 mL) is stirred at room temperature for 12 h. The volatiles are removed under reduced pressure, and the resulting crude 4-amino nicotinic acid is used directly in the next reaction.

후처리

  1. customThe volatiles are removed under reduced pressure
  2. customthe resulting crude 4-amino nicotinic acid is used directly in the next reaction

출처 및 근거

ORD 기록
ord-f28ae5e3b9764bcab2804e3869caafe6
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06455534B2

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