Potassium Carbonate → 2-[4-(2-oxo-1,3-Oxazolidin-3-yl)phenyl]propanoic Acid

HRID 1282020

반응식

HRID 1282020 반응식
Cl[CH2:2][CH2:3][O:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH3:18])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=1)=[O:6].C(=O)([O-])[O-].[K+].[K+].C(OC(=O)C)C.C(OC(C)C)(C)C>CN(C)C=O>[O:6]=[C:5]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]([CH3:18])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)[CH2:2][CH2:3][O:4]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 184235752-(4-{[(2-Chloroethoxy)carbonyl]amino}phenyl)propanoic AcidHCID 22281796Diisopropylether ethyl acetate

생성물 1

HCID 120432422-[4-(2-oxo-1,3-Oxazolidin-3-yl)phenyl]propanoic Acid수율 80.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.5 g (1.85 mmol) of 2-(4-{[(2-chloroethoxy)carbonyl]amino}phenyl)propanoic acid were dissolved in 10 ml of N,N-dimethylformamide and 0.45 g (3.7 mmol) of potassium carbonate were added. After 48 hours the solvent was evaporated under vacuum, the residue redissolved with dichloromethane and washed with hydrochloric acid 0.5 N. The organic layer was dried over sodium sulphate and evaporated. 0.35 g (80% yield) of the title compound crystallized from a mixture ethylacetate-diisopropylether.

후처리

  1. customAfter 48 hours the solvent was evaporated under vacuum
  2. dissolutionthe residue redissolved with dichloromethane
  3. washwashed with hydrochloric acid 0.5 N
  4. dry with materialThe organic layer was dried over sodium sulphate
  5. customevaporated

출처 및 근거

ORD 기록
ord-4e45ff92dcff41428fe741d375b28032
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06455559B1

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