Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine → 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-(2-Bromoethoxy)-1,3-dimethylbenzene | HCID 2452208 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine | HCID 23468652 | — |
반응 단계
To methylethylketone (1 liter) are added 2-(2,6-dimethylphenoxy)-1-bromo-ethane (132 g), sodium iodide (85 g), potassium carbonate (80 g) and piperazine (200 g). The mixture is refluxed for 24 hours, with stirring. After cooling, the mixture is filtered and then washed with 3×300 ml benzene. After evaporation of the benzene, the piperazine derivative is distilled; b.p. 25 mm Hg=190° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04259334 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-81ef5e212bdb488faab82b396a9fc6ad |
| 출처 메모 | uspto-grants-1981_03 |