Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylenetriphenylphosphorane → 17-Cyclopropylmethyl-3-hydroxy-6-methylene-morphinan
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylenetriphenylphosphorane | HCID 137960 | — |
| 반응물 | 17-Cyclopropylmethyl-3-hydroxy-morphinan-6-one | HCID 6602257 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 17-Cyclopropylmethyl-3-hydroxy-6-methylene-morphinan | HCID 54412485 | — |
반응 단계
Reaction of 17-cyclopropylmethyl-3-hydroxy-morphinan-6-one (1.58 g, 5 mmole) with methylenetriphenylphosphorane (20 mmole) in dimethyl sulfoxide gave a crude residue which was chromatographed using 10:1 chloroform-methanol containing 1% concentrated ammonium hydroxide. Pure fractions were pooled to give 909 mg (58%) of TR-5609 which crystallized from ethanol to give 532 mg of analytically pure TR-5609, mp 220°-223°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04259329 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-d7ffcb5aa64b450d96fe70fcc9e98e58 |
| 출처 메모 | uspto-grants-1981_03 |