Water → 4-Methoxy-2-(piperazin-1-yl)pyrimidine

HRID 1282167노트

반응식

HRID 1282167 반응식
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.O>C(#N)C>[CH3:9][O:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[N:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 4837PiperazineHCID 5889352-Chloro-4-methoxypyrimidine

생성물 1

HCID 114809874-Methoxy-2-(piperazin-1-yl)pyrimidine수율 90%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A suspension of 2-chloro-4-methoxypyrimidine (21.5 g) and piperazine (64.0 g) in acetonitrile (200 ml) was refluxed for 30 min. The reaction mixture was poured into water (500 ml) and extracted with chloroform (400 ml). The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound (26.0 g) as a pale-yellow oil.

후처리

  1. temperaturewas refluxed for 30 min
  2. extractionextracted with chloroform (400 ml)
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-5c2dcbca42a644a7b85acf3e1349d051
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06455528B1

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