Water → HCID 18423027, 화합물

HRID 1282188노트

반응식

HRID 1282188 반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1.[Br:14][C:15]1[S:19][C:18]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Br:14][C:15]1[S:19][C:18]([N:20]2[CH2:21][CH2:22][N:23]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=3)[CH2:24][CH2:25]2)=[N:17][CH:16]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 15550682N-((4-(chloromethyl)phenyl)methyl)acetamideHCID 184230061-(5-Bromo-1,3-thiazol-2-yl)piperazine

생성물 1

HCID 18423027HCID 18423027, 화합물수율 82.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of N-(4-chloromethylphenylmethyl)acetamide (0.9 g), 1-(5-bromothiazol-2-yl)piperazine (1.1 g) and potassium carbonate (0.9 g) in dimethylformamide (10 ml) was stirred at 70° C. for 9 hr. Water (100 ml) was poured into the reaction mixture to allow precipitation of crystals. The crystals were collected by filtration and washed with water to give the title compound (1.5 g) as yellow crystals, m.p.=160-163° C.

후처리

  1. customprecipitation of crystals
  2. filtrationThe crystals were collected by filtration
  3. washwashed with water

출처 및 근거

ORD 기록
ord-cfee12241c164bfab5c85e3ab6c8f4c2
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06455528B1

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