Imidazole → 1-[2-Cyano-2-(4-phenylthiophenyl)hexyl]imidazole

HRID 128226노트

반응식

HRID 128226 반응식
[C:1]([C:3]([C:10]1[CH:15]=[CH:14][C:13]([S:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:4]Br)#[N:2].[NH:23]1[CH:27]=[CH:26][N:25]=[CH:24]1>O>[C:1]([C:3]([C:10]1[CH:15]=[CH:14][C:13]([S:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:4][N:23]1[CH:27]=[CH:26][N:25]=[CH:24]1)#[N:2]

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 542149592-Cyano-2-(4-phenylthiophenyl)hexyl bromide

생성물 1

HCID 540197231-[2-Cyano-2-(4-phenylthiophenyl)hexyl]imidazole수율 82%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 10 g (0.027 mole) of 2-cyano-2-(4-phenylthiophenyl)hexyl bromide and 8 g (0.13 mole) of imidazole is heated with stirring at 160° for four hours. The reaction mixture is poured into water and extracted with ether. The combined ether extracts are washed with water and dried over Na2SO4. The drying agent is filtered and to the filtrate is bubbled dry hydrogen chloride gas until solution is strongly acidic. The hydrochloride salt is washed with ether and back neutralized with dilute ammonium hydroxide solution to give 8 g of pure product.

후처리

  1. temperatureis heated
  2. extractionextracted with ether
  3. washThe combined ether extracts are washed with water
  4. dry with materialdried over Na2SO4
  5. filtrationThe drying agent is filtered and to the filtrate
  6. customis bubbled dry hydrogen chloride gas until solution
  7. washThe hydrochloride salt is washed with ether

출처 및 근거

ORD 기록
ord-b1883a291f8f49158cdfcc690bf2f2d1
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259339

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