Dehydrolinalool → 2H-Pyran, 2-ethynyltetrahydro-2,6,6-trimethyl-
반응식
[CH3:1][C:2]([CH3:11])=[CH:3][CH2:4][CH2:5][C:6]([OH:10])([C:8]#[CH:9])[CH3:7]>C(OC)(C)(C)C>[C:8]([C:6]1([CH3:7])[CH2:5][CH2:4][CH2:3][C:2]([CH3:11])([CH3:1])[O:10]1)#[CH:9]참가 물질
3
실험 절차
A solution of 13.82 g (0.09 mol) of dehydrolinalool (II, R1, R2 and R3 =methyl) in 200 ml of methyl tert.butyl ether was added to 28.35 g of Zeocat® Z6-05-02 and stirred for 30 min. The reaction mixture was evaporated (40° C., 300 mbar) and the resulting solid was subjected to microwave irradiation (600 W power for 4 s). The product was separated from the solid by dissolving in 300 ml acetone and evaporating the solvent in vacuo. The crude 2-ethinyl-tetrahydro-2,6,6-trimethylpyran was obtained in 13.30 g (96.2%) yield as yellowish liquid.
후처리
- customThe reaction mixture was evaporated (40° C., 300 mbar)
- customthe resulting solid was subjected to microwave irradiation (600 W power for 4 s)
- customThe product was separated from the solid
- dissolutionby dissolving in 300 ml acetone
- customevaporating the solvent in vacuo
출처 및 근거
- ORD 기록
- ord-20004b551fa44c108ce00d9eeefe254d
- 출처 데이터셋
- uspto-grants-2002_09
- 특허 번호
- US06455707B1
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