Potassium Carbonate → trans 2-Bromo-6-chlorobenzyl 2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropane carboxylate

HRID 128245노트

반응식

HRID 128245 반응식
[Cl:1][C:2]([Cl:12])=[CH:3][C@@H:4]1[C:6]([CH3:8])([CH3:7])[C@H:5]1[C:9]([OH:11])=[O:10].[Br:13][C:14]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:15]=1[CH2:16]Br.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.O>[Cl:1][C:2]([Cl:12])=[CH:3][C@@H:4]1[C:6]([CH3:8])([CH3:7])[C@H:5]1[C:9]([O:11][CH2:16][C:15]1[C:18]([Cl:22])=[CH:19][CH:20]=[CH:21][C:14]=1[Br:13])=[O:10]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 41539Trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acidHCID 27568722-Bromo-6-chlorobenzyl bromide

생성물 1

HCID 131712138trans 2-Bromo-6-chlorobenzyl 2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropane carboxylate수율 98%

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

실험 절차

1 cis/trans 2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropane carboxylic acid (2.3 g), 2-bromo-6-chlorobenzylbromide (2.85 g) and potassium carbonate (1.6 g) were stirred together in acetone (30 ml) under reflux for 6 hours. The reaction mixture was cooled, diluted with water, and extracted three times with 50 ml portions of diethyl ether. The combined ether extracts were washed with water and with aqueous sodium bicarbonate solution (three times), dried over magnesium sulphate and evaporated to give the orange title product (4. g, 98%) m.p. 61°-67° C.

후처리

  1. temperatureunder reflux for 6 hours
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted three times with 50 ml portions of diethyl ether
  4. washThe combined ether extracts were washed with water and with aqueous sodium bicarbonate solution (three times)
  5. dry with materialdried over magnesium sulphate
  6. customevaporated

출처 및 근거

ORD 기록
ord-86a8a7b9788b4e6e9447e9f7d06881be
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259349

반응 노트

불러오는 중…